Search results for "Basal Ganglia Hemorrhage"

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Neuroprotective effect of erythropoietin and darbepoetin alfa after experimental intracerebral hemorrhage.

2009

OBJECTIVE: Intracerebral hemorrhage (ICH) is a devastating clinical syndrome for which no truly efficacious therapy has yet been identified. In preclinical studies, erythropoietin (EPO) and its long-lasting analog, darbepoetin alfa, have been demonstrated to be neuroprotective in several models of neuronal insult. The objectives of this study were to analyze whether the systemic administration of recombinant human EPO (rHuEPO) and its long-lasting derivative darbepoetin alfa expedited functional recovery and brain damage in a rat model of ICH. METHODS: Experimental ICH was induced in rats by injecting autologous blood into the right striatum under stereotactic guidance. Subsequently, animal…

Brain InfarctionMaleDarbepoetin alfaBrain EdemaBrain damageNeuroprotectionDrug Administration ScheduleCentral nervous system diseaseRats Sprague-DawleyBlood Transfusion AutologousErythropoietin; Erythropoietin derivative; Intracerebral hemorrhage; Neuroprotectionhemic and lymphatic diseasesEdemamedicineAnimalsHumansDarbepoetin alfaErythropoietinCerebral HemorrhageIntracerebral hemorrhagebusiness.industryBasal Ganglia HemorrhageBrainmedicine.diseaseNeuroprotectionCorpus StriatumRecombinant ProteinsRatsErythropoietin derivativeDisease Models AnimalNeuroprotective AgentsTreatment OutcomeErythropoietinAnesthesiaErythropoietin Erythropoietin derivative Intracerebral hemorrhage NeuroprotectionSystemic administrationHematinicsSurgeryNeurology (clinical)medicine.symptomIntracerebral hemorrhagebusinessmedicine.drugNeurosurgery

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